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Articles

Vol. 1 No. 4 (2026): September

Antibiotic Susceptibility Patterns of Clinical Staphylococcus aureus Isolates at Inche Abdoel Moeis Regional General Hospital, Samarinda, July 2024–July 2025

Submitted
August 13, 2026
Published
2026-09-30

Abstract

Background: Antibiotic resistance in Staphylococcus aureus is a global health concern that affects the effectiveness of bacterial infection treatment. Local surveillance of antibiotic susceptibility patterns is necessary to support rational empirical antibiotic selection. This study aimed to determine the antibiotic susceptibility patterns of Staphylococcus aureus isolates at RSUD Inche Abdoel Moeis, Samarinda, during the period from July 2024 to July 2025.

Methods: This descriptive study employed a cross-sectional design using culture results of Staphylococcus aureus from clinical specimens examined at the Microbiology Laboratory of RSUD Inche Abdoel Moeis, Samarinda. The study sample consisted of 25 Staphylococcus aureus isolates that met the inclusion criteria and were obtained from various clinical specimens. Antibiotic susceptibility data were obtained from secondary laboratory records at RSUD Inche Abdoel Moeis for 20 antibiotics tested.

Results: Based on the antibiotic susceptibility patterns, Staphylococcus aureus isolates showed high resistance to β-lactam antibiotics, including ampicillin, penicillin G, and cefoxitin, across nearly all types of clinical specimens. In contrast, non-β-lactam antibiotics, including nitrofurantoin, trimethoprim, and high-level mupirocin, were predominantly classified as susceptible, with high susceptibility observed across all specimens and relatively low resistance rates. The most frequently represented specimens were blood, pus, and sputum, each accounting for 28% of the isolates, followed by urine, bone, and tissue.

Conclusion: The findings indicate that several β-lactam antibiotics are no longer effective as empirical therapy for Staphylococcus aureus infections at RSUD Inche Abdoel Moeis, Samarinda. Therefore, local antibiotic susceptibility data are needed to support rational antibiotic use and help reduce the burden of antimicrobial resistance in hospitals

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